It is primarily used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). As a serotonin-norepinephrine reuptake inhibitor (SNRI), Duloxetine helps to balance the levels of serotonin and norepinephrine in the brain, which can improve mood, alleviate anxiety, and enhance overall emotional stability. It is also prescribed for managing chronic pain conditions, such as fibromyalgia and neuropathic pain associated with diabetes (diabetic peripheral neuropathy). Additionally, Duloxetine can be used to treat chronic musculoskeletal pain, including osteoarthritis and chronic lower back pain. The medication should be used under medical supervision to monitor for side effects, which may include nausea, dry mouth, drowsiness, and changes in blood pressure.